Irf3 mouse
WebDuring infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kinase complex that includes IKKε and TBK1 (6,7). IRF-3 is … http://www.informatics.jax.org/marker/MGI:1859179
Irf3 mouse
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IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. IRF3 is found … WebMar 21, 2024 · IRF3 (Interferon Regulatory Factor 3) is a Protein Coding gene. Diseases associated with IRF3 include Encephalopathy, Acute, Infection-Induced 7 and …
WebJul 11, 2016 · IRF3 expression is elevated in adipocytes from obese mice and humans. To determine whether IRF3 plays a role in obesity-associated dysfunction of adipose tissue, we began by asking whether IRF3 expression is elevated in the fat cells of obese mice. WebWe previously showed that interferon regulatory factor 3 (IRF3) contributes to sepsis pathogenesis in young mice subject to cecal ligation and puncture (CLP). In this study, we investigated if IRF3 contributes to sepsis in the context of aging. ... Two-way repeated measures ANOVA was used to compare the mouse surface temperature and disease ...
WebHere we examined the role of IRF3 in expression of innate anti-viral proteins produced in response to IFN-γ plus TLR3 agonist. Wild-type (WT) and IRF3KO RAW264.7 cells, each with ISG54-promoter-luciferase reporter vectors, were stimulated with IFN-γ, poly I:C, or both together. ISG54 promoter activity was significantly reduced in IRF3KO ... WebIrf3 stringent orthology 1 human;1 mouse;1 rat;1 zebrafish. HCOP. vertebrate homology predictions: IRF3. Gene Tree. Irf3. Human Diseases more. Diseases 1 with human IRF3 associations ... Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann Hum Genet. 1998 May;62(Pt …
WebOct 15, 2013 · Double-deficient Irf-3(-/-)7(-/-) mice infected with the DENV2 strain S221 possessed 1,000-150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 h postinfection (hpi); however, they remained resistant to lethal infection.
WebNov 2, 2024 · Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote … list of shot types in filmWebFlow cytometric analysis of adipocytes from wild type mice, untransfected (A) or transfected with Poly (I:C) (2.5 µg/ml, 6 hr; B), and adipocytes from IRF-3 (-/-) mice, untransfected (C) or transfected with Poly (I:C) (2.5 µg/ml, 6 hr; D), using Phospho-IRF … list of shots bar servesWebJan 18, 2024 · The TFs interferon regulatory factor 3 (IRF3), IRF5 and IRF7 (IRF3/5/7) ... To understand the role of DNA binding in IFN regulation, we mapped the binding of IRF3/5/7 dimers to all human and mouse IFN gene VREs. We found that IRF3 and IRF7 bind across many of the VRE sub-elements, but that the VRE-A/B sub-element is bound almost … list of shows available on paramount plusWebMar 4, 2024 · We next examined the endogenous association between IRF3 and USP22, and immunoblot analysis revealed that USP22 interacted with IRF3 in mouse bone marrow–derived dendritic cells (BMDCs) and MEFs after SeV or HSV-1 infection . USP22 has been reported to be localized in cytoplasm and nucleoplasm (Xiong et al., 2014). immature selfish man childlist of shoulder injuriesWebJan 15, 2024 · IFN regulatory factor 3 (IRF3) is a transcription factor that is activated by multiple pattern-recognition receptors. We demonstrated previously that IRF3 plays a … immature series watchWebJul 7, 2024 · However, the published Irf3 −/− mice that were previously tested are also deficient in Bcl2l12, a gene that neighbors Irf3 and which was inadvertently disrupted by the deletion targeting Irf3 44. list of shows available on britbox