Fth1 cell

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http://img1.bioon.com/news/showarticle.asp?newsid=112585 WebApr 12, 2024 · Iron is essential for life. Many enzymes require iron for appropriate function. However, dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species (ROS) via the Fenton reaction and causes devastating effects on cells, leading to ferroptosis, an iron-dependent cell death. In order to protect against harmful …

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WebDec 29, 2024 · Background Ferroptosis is a newly identified type of programmed cell death, which preferentially targets iron-rich cancer cells such as hepatocellular carcinoma … WebHuman cell lines. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions … ahla staff

Iron derived from autophagy-mediated ferritin degradation ... - eLife

WebMay 6, 2024 · It is demonstrated that developing inhibitors for the NCOA4–FTH1 interaction is a new strategy to halt ferroptosis and develop novel therapeutic solutions to combat neurological diseases, such as ischemic stroke. Results and Discussion Discovery of a Potent Ferroptosis Inhibitor WebMar 21, 2024 · FTH1 (Ferritin Heavy Chain 1) is a Protein Coding gene. Diseases associated with FTH1 include Hemochromatosis, Type 5 and Macular Dystrophy, … WebAug 12, 2016 · Consistently, inhibition of ferritinophagy by blockage of autophagy or knockdown of NCOA4 abrogated the accumulation of ferroptosis-associated cellular labile iron and reactive oxygen species, as... ahla shared diagnostic facility

Subcellular location of FTH1 - The Human Protein Atlas

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major … See more Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. FTH1 gene is located on chromosome 11, and its mutation causes Hemochromatosis type 5. See more FTH1 has been shown to interact with ferritin light chain. See more • Percy ME, Wong S, Bauer S, Liaghati-Nasseri N, Perry MD, Chauthaiwale VM, Dhar M, Joshi JG (January 1998). "Iron metabolism and human ferritin heavy chain cDNA from … See more • Ferritin See more WebNational Center for Biotechnology Information onenote 段落番号ずれる onenote 共有リンクアプリで開く

"WebOct 5, 2015 · Through analysis of the NCOA4-FTH1 interaction, we demonstrate that direct association via a key surface arginine in FTH1 and a C-terminal element in NCOA4 is required for delivery of ferritin to the lysosome via autophagosomes. Moreover, NCOA4 abundance is under dual control via autophagy and the ubiquitin proteasome system. " - Fth1 cell

Fth1 cell

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WebMar 17, 2024 · Ferroptotic cell death has also been associated with dysfunction of the intestinal epithelium, which contributes to several intestinal diseases. ... FTL ferritin light chain, FTH1 ferritin heavy ... WebDec 21, 2024 · Within expectation, a simultaneous degradation of NCOA4 and FTH1 was observed in cisplatin-treated BUMPT cells, which was partially restored by myo-inositol treatment (Figure 3O, lanes 1 and 2). All in all, these in vitro data indicated that myo -inositol down-regulates the expression profile of NOX4 to decelerate ferroptosis in cisplatin ...

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WebApr 5, 2024 · results showed the association of secreted IL-10, FHC and iron homoeostasis in Chlamydia trachomatis-infected HeLa-229 cells; FTH1 is a functional target gene of … WebFTH1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.

WebMay 19, 2024 · BACKGROUND Serum ferritin is a useful tumor marker for renal cell carcinoma (RCC). However, the expression of ferritin heavy chain (FTH1), the main … WebFTH1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. …

WebMar 3, 2024 · “MMRi62 causes degradation of an iron-storage protein called FTH1, as well as a protein that is mutated in PDAC, resulting inhibition of metastasis and ferroptosis, a form of cell death triggered by free cellular iron,” says Xinjiang Wang, PhD, Associate Professor in the Department of Pharmacology and Therapeutics at Roswell Park.. … WebHowever, FTH1-overexpression-related cytotoxicity is required to be explored. METHODS: By using the Tet-Off system, FTH1 overexpression was semi-quantitativiely and dynamicly regulated by doxycycline in a NPC cell line. Effects of FTH1 overexpression on the proliferation, cytotoxicity, apoptosis and migration of NPC cells were investigated in ...

WebApr 3, 2024 · To further examine whether iron overload is caused by ferritinophagy, we assessed the effect of Sch B on the expression of FTH1 in cultured LX2 cells. The protein expression of FTH1 was increased by Sch B (Figure 4(e)). Additionally, Sch B promoted the binding of NCOA4 to FTH1 in vitro (Figure 4(f)). Collectively, these data suggested that …

WebDec 2, 2024 · In general, ferroptosis is a form of inflammatory cell death associated with the release of DAMPs (e.g., high mobility group box 1 (HMGB1) and DNA) or lipid oxidation products (e.g., 4HNE, oxPLs ... ahla san franciscoWebImmune cell proteome. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. FTH1. onenote 図形テキストWebFTH1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. Assigned HPA protein class (es) for the encoded ... ahl.avacentWebMar 24, 2024 · Downregulation of miR-21-5p suppressed the level of MELK and the progression of HCC. MELK regulated the AKT/mTOR signaling pathway, causing changes in the levels of GPX4, GSH, FTH1, xCT, heme oxygenase 1(HO-1), reactive oxygen species, and Fe 2+ to regulate the ferroptosis of hepatoma cells. Erastin, an inducer of … ah lattice\u0027sWebSubcellular location of FTH1. Localized to the microtubules. Analysis based on one antibody, CAB008623, using immunofluorescence in human cells ... Analysis based on … onenote 表示変更セクションWebDec 15, 2015 · While IRP ablation in DC expectedly increased basal FTH1 protein levels, it did not prevent FTH1 stimulation by LPS (Figure S4 D). Hence, LPS regulation of FTH1 in DC is largely independent of the IRP/IRE system and could reflect alternative IRP-independent regulation of FTH1 as, for instance, observed in fibrosarcoma cells ( Daba … ahl attendance 2020-21WebOct 19, 2014 · Analysis of NCOA4 −/− cell extracts using SEC revealed that the faster-migrating FTH1 band was absent in all fractions, and that the relative amount of FTH1 and FTL was greater in fractions ... oneoffice スマートコネクト印刷